Hypoxia-Inducible Factor (HIF) activators Xenon and Argon have been added to the World Anti-Doping Code Prohibited List, effective from 1 September 2014.
Both are prohibited under section S2 Peptide Hormones, Growth Factors and Related Substances, banned for use in and out-of-competition. The change is made following recommendation at the April World Anti-Doping Agency (WADA) List Committee meeting and the conclusion of the required three-month notice period.
The change to the List reads as follows:
S2. PEPTIDE HORMONES, GROWTH FACTORS AND RELATED SUBSTANCES
The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited:
1. Erythropoiesis-Stimulating Agents [e.g. erythropoietin (EPO), darbepoetin (dEPO), hypoxia-inducible factor (HIF) stabilizers and activators (e.g. xenon, argon), methoxy polyethylene glycol-epoetin beta (CERA), peginesatide (Hematide)]